Prediction of Potential Mutation of Chicken Coronavirus into Future Human Coronavirus Based on Spike S1 Glycoprotein Gene

The high mutation rates of the chicken coronavirus (IBV) cause economic threats to poultry industry. However, most dangerous situation is likelihood changing its sequences into human (COVID-19-like virus). Therefore, in present study we aimed investigate possibility genetic IBV COVID-19. Thus, Spike (S1) Glycoprotein genes both and COVID-19 were aligned, analyzed calculated predict possible changes that could happen S1. results indicated case an independent function probability each cluster S1 sequences, potential rate be as was equal 1.87E-96. because tendency for some sequence clusters gene low or zero, it unattainable mutate sequence. Furthermore, dependent function, assumed annual make infectious may reach up around 50% after about 260 years. As a conclusion, mutating COVID-19-like virus not impossible, but might take substantial period time